1. What are polynucleotides?
Polynucleotides are long chains of nucleotides (the building blocks of DNA and RNA) derived from purified salmon DNA. In aesthetics, they’re used as injectable biostimulators to repair skin, stimulate collagen, and improve skin quality at a cellular level.
2. How do polynucleotides work?
Once injected into the skin, polynucleotides:
- Stimulate fibroblasts (cells that produce collagen and elastin)
- Promote tissue regeneration and healing
- Increase hydration by stimulating hyaluronic acid production
- Reduce inflammation and oxidative stress
This makes them ideal for improving skin texture, elasticity, and overall skin health.
3. What are the benefits of polynucleotide injections?
- Improves skin tone, texture, and elasticity
- Reduces fine lines and early signs of aging
- Hydrates and rejuvenates dull or tired skin
- Helps treat acne scars and sun damage
- Can calm inflamed or sensitive skin
- Often used around eyes, face, neck, décolletage, and hands
4. Are polynucleotides the same as fillers?
No. Polynucleotides are bioregenerative, not volumizing like dermal fillers. They improve skin quality rather than adding volume.
5. How many sessions are needed?
Typically:
- 3–4 sessions, spaced 2–4 weeks apart for optimal results
- Maintenance treatments every 4–6 months depending on your skin needs
6. When will I see results?
- Some people notice improved hydration and glow within a few days
- Collagen-stimulating effects typically appear after 3–6 weeks
- Full benefits develop progressively with continued treatment
7. Is the treatment painful?
Discomfort is minimal. A fine needle or cannula is used, and a numbing cream is often applied beforehand. Most people tolerate it well.
8. Is there downtime after polynucleotide injections?
Downtime is minimal. You may experience:
- Mild redness or swelling at injection sites
- Occasional bruising or tenderness
These typically resolve within 24–72 hours.
9. Are polynucleotides safe?
Yes. They are:
- Biocompatible
- Non-immunogenic (unlikely to cause allergic reactions)
- Clinically used for years in wound healing and ophthalmology
However, they should be administered by a trained medical professional.
10. Who is a good candidate?
Polynucleotides are great for:
- Anyone seeking natural skin rejuvenation
- People with dull, dehydrated, or aging skin
- Sensitive skin types (they help calm and repair)
- Those looking for preventative skin treatments in their 20s–30s
11. Are polynucleotides suitable for under-eye treatment?
Yes! They are especially popular for the under-eye area, helping reduce:
- Dark circles
- Fine lines
- Thin, crepey skin
They hydrate and strengthen the delicate under-eye skin.
12. Can I combine polynucleotides with other treatments?
Absolutely. They pair well with:
- Microneedling
- PRP (Platelet-Rich Plasma)
- Light chemical peels
- Botox and dermal fillers (in separate sessions)
Always follow your provider’s guidance on combining treatments.
13. How are polynucleotides different from Profhilo or Skinboosters?
| Treatment | Main Function | Key Ingredient | Volume Added | Results Timeline |
|---|---|---|---|---|
| Polynucleotides | Regeneration & repair | DNA fragments (salmon-derived) |  No | Gradual (weeks) |
| Profhilo | Hydration & lift | Hyaluronic Acid (HA) |  Mild | Fast (days–weeks) |
| Skinboosters | Deep hydration | HA-based | Mild | Quick (days–weeks) |
14. Are there any side effects or risks?
- Mild swelling, bruising, or tenderness at injection sites
- Rare allergic reactions (very uncommon)
- Temporary small lumps that settle quickly
Always choose a licensed, experienced injector to minimize risk.
